ENFERMEDAD DE HODGKIN. ACTUALIZACIÓN
Dr. Horacio Oliva
1. Alvaro
Naranjo T, Salvado Usach MT, Bosch Princep R, Martinez
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value of histopathologic parameters in Hodgkin's disease,
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Piris MA, Abraira V, Acevedo A, Aguilera B, Bellas C, Fraga
M, Garcia-Del-Moral R, Gomez-Marcos F, Menarguez J, et al.
Adverse clinical outcome in Hodgkin's disease is associated
with loss of retinoblastoma protein expression, high Ki67
proliferation index, and absence of Epstein-Barr virus-latent
membrane protein 1 expression [In Process Citation]. Blood
1997;90:2429-36.
8.
Orschesche K, Merz H, Hell J, Feller AC. Presence of the
t(2;5) in Hodgkin's disease [letter; comment]. Blood
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9.
Sanchez-Beato M, Martinez-Montero JC, Doussis-Anagnostopoulou
TA, Gatter KC, Garcia J, Garcia JF, LLoret E, Piris MA.
Anomalous retinoblastoma protein expression in Sternberg-Reed
cells in Hodgkin's disease: a comparative study with p53 and
Ki67 expression. Br J Cancer 1996;74:1056-62.
10. Tilly H,
Bastard C, Delastre T, Duval C, Bizet M, Lenormand B, Dauce
JP, Monconduit M, Piguet H. Cytogenetic studies in untreated
Hodgkin's disease. Blood 1991;77:1298-304.
11. Yee HT, Ponzoni M,
Merson A, Goldstein M, Scarpa A, Chilosi M, Menestrina F,
Pittaluga S, de Wolf-Peeters C, Shiota M, et al. Molecular
characterization of the t(2;5) (p23; q35) translocation in
anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease.
Blood 1996;87:1081-8.
 |
Figura 18. p53 en enfermedad
de Hodgkin. Sólo las células grandes atípicas,
de Hodgkin y R-S
muestran inmunotinción, no existiendo elementos
linfoides de pequeño o mediano tamaño
positivos.
Cerca del 100% de los casos de enfermedad de
Hodgkin son positivos. P53. En la foto se
observan células de Reed-Sternberg positivas
para p53. |
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