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Inside (immediately before bed) in a single dose of 10 mg. In elderly or debilitated patients, if liver function is impaired, treatment is started with a dose of 5 mg. If necessary (insufficient clinical effect) and good tolerability of the drug, the dose may be increased to 10 mg. The maximum daily dose is 10 mg. The course of treatment should not exceed 4 weeks. With transient insomnia, the recommended course of treatment is 2-5 days, in case of a situational one - 2-3 weeks.
Very short periods of treatment do not require the gradual withdrawal of the drug. In the case of long-term use of the drug to reduce the possibility of development of ricochet insomnia, the abolition of zolpidem should be carried out gradually (first a decrease in the daily dose and then the withdrawal of the drug).


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Alcohol enhances the sedative effect of zolpidem, joint use is not recommended. Drugs that act depressingly on the central nervous system (neuroleptics, barbiturates, other sleeping pills, anxiolytics / sedatives, antidepressants with sedative action, narcotic analgesics, antitussive central action), antiepileptic drugs, general anesthetics, antihistamines with sedative effect, antihypertensive central action; baclofen; thalidomide; pizotifen - when combined, there is an intensification of the oppressive effect on the central nervous system and the risk of respiratory depression increases; buprenorphine - risk of respiratory depression; ketoconazole (a powerful inhibitor of CYP3A4) reduces the clearance of zolpidem, in connection with which it is possible to increase its sedative effect; itraconazole (inhibitor CYP3A4) - a slight, clinically insignificant change in the pharmacokinetics and pharmacodynamics of zolpidem. Rifampicin (inducer CYP3A4) accelerates metabolism, reduces the concentration and effectiveness of zolpidem.

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Overdose Symptoms: European post-marketing reports on zolpidem overdose report a violation of consciousness (from drowsiness to mild coma). Fixed one case of cardiovascular and respiratory disorders. There was a complete recovery after taking doses of zolpidem tartrate to 400 mg (40 times greater than MPDH).Cases of overdose caused by the simultaneous administration of many drugs, depressing the central nervous system, including zolpidem, led to more severe consequences, up to lethal outcomes.Treatment: induction of vomiting or immediate gastric lavage (depending on the condition), the purpose of activated charcoal. The monitoring of vital functions (breathing, pulse, blood pressure, etc.) is shown, if necessary, symptomatic and supportive therapy. It should be abandoned the use of any sedatives (even with pronounced stimulation).

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Before taking zolpidem, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, mental/mood problems (such as depression, thoughts of suicide), personal or family history of regular use/abuse of drugs/alcohol/other substances, personal or family history of sleepwalking, lung/breathing problems (such as chronic obstructive pulmonary disease-COPD, sleep apnea), a certain muscle disease (myasthenia gravis). Discuss the risks and benefits with your doctor. A small amount of this medication passes into breast milk. Consult your doctor before breast-feeding. Avoid alcoholic beverages. Older adults may be more sensitive to the effects of this drug, especially dizziness, confusion, unsteadiness, and excessive drowsiness.

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Ambien (Zolpidem) is a prescription medication used for short term treatment of insomnia. It belongs to a group of drugs called sedative-hypnotics that work by depressing the central nervous system and slowing down brain activity? While Ambien is generally considered safer than certain other sedatives, it can still be misused. Long-term use may lead to tolerance, dependence, and withdrawal.
When used as prescribed, the traditional form of the drug is taken at bedtime to help users fall asleep. The extended-release version hit the market in 2005 with two layers - the first to put you to sleep and the second, internal layer helped to keep you that way. According to Forbes Magazine, US physicians doled out 40 million prescriptions for the sedative hypnotic drug in 2011.


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