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We estimate that approximately 6%?0 of US adults used these drugs in 2010, and the percentages may be higher in parts of Europe.1 2 By 1979, the Cancer Prevention Study I of the American Cancer Society had found that both cigarette smoking and hypnotic consumption were associated with excessive deaths,3 4 but the hypnotic findings were discounted since the Cancer Prevention Study I was not designed primarily to study these drugs. 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